https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 COPD in Africa: risk factors, hospitalisation, readmission and associated outcomes-a systematic review and meta-analysis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52580 Wed 28 Feb 2024 15:38:52 AEDT ]]> Multidimensional assessment and tailored interventions for COPD: respiratory utopia or common sense? https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17148 Wed 11 Apr 2018 17:15:05 AEST ]]> Asthma exacerbations during pregnancy: incidence and association with adverse pregnancy outcomes https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1226 Wed 11 Apr 2018 16:52:40 AEST ]]> Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22168 -/-) BALB/c mice were intranasally sensitised and challenged with HDM prior to infection with RV1B. In some experiments, mice were administered recombinant IFN or adoptively transferred with plasmacytoid dendritic cells (pDC). Results: Allergic Tlr7-/- mice displayed impaired IFN release upon RV1B infection, increased virus replication and exaggerated eosinophilic inflammation and airways hyper reactivity. Treatment with exogenous IFN or adoptive transfer of TLR7-competent pDCs blocked these exaggerated inflammatory responses and boosted IFNγ release in the absence of host TLR7 signalling. TLR7 expression in the lungs was suppressed by allergic inflammation and by interleukin (IL)-5-induced eosinophilia in the absence of allergy. Subjects with moderate-to-severe asthma and eosinophilic but not neutrophilic airways inflammation, despite inhaled steroids, showed reduced TLR7 and IFNλ2/3 expression in endobronchial biopsies. Furthermore, TLR7 expression inversely correlated with percentage of sputum eosinophils. Conclusions: This implicates IL-5-induced airways eosinophilia as a negative regulator of TLR7 expression and antiviral responses, which provides a molecular mechanism underpinning the effect of eosinophil-targeting treatments for the prevention of asthma exacerbations.]]> Wed 11 Apr 2018 15:36:21 AEST ]]> Asthma exacerbations 3: pathogenesis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1059 Wed 11 Apr 2018 14:05:04 AEST ]]> Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4347 Wed 11 Apr 2018 11:56:12 AEST ]]> Prenatal origins of bronchiolitis: protective effect of optimised asthma management during pregnancy https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17208 Wed 11 Apr 2018 10:35:28 AEST ]]> New reference ranges for interpreting forced expiratory manoeuvres in infants and implications for clinical interpretation: a multicentre collaboration https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24089 Wed 09 Feb 2022 15:53:18 AEDT ]]> Endoplasmic reticulum-unfolded protein response signalling is altered in severe eosinophilic and neutrophilic asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49760 Tue 30 May 2023 18:39:10 AEST ]]> Maternal asthma is associated with reduced lung function in male infants in a combined analysis of the BLT and BILD cohorts https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46724 Tue 29 Nov 2022 11:27:33 AEDT ]]> Higher exhaled nitric oxide at 6 weeks of age is associated with less bronchiolitis and wheeze in the first 12 months of age https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48952 Tue 02 May 2023 11:43:55 AEST ]]> A randomised trial of hypertonic saline during hospitalisation for exacerbation of cystic fibrosis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30031 Thu 28 Oct 2021 13:04:21 AEDT ]]> A novel immunomodulatory function of neutrophils on rhinovirus-activated monocytes in vitro https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25846 Thu 28 Oct 2021 12:37:11 AEDT ]]> Neutrophils in asthma: The good, the bad and the bacteria https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53382 Thu 23 Nov 2023 12:54:42 AEDT ]]> The overlap syndrome of asthma and COPD: what are its features and how important is it? https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:8375 Sat 24 Mar 2018 08:39:49 AEDT ]]> Tackling asthma phenotypes in community studies https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7024 Sat 24 Mar 2018 08:37:51 AEDT ]]> Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9358 Sat 24 Mar 2018 08:36:33 AEDT ]]> The effect of cigarette smoking on asthma control during exacerbations in pregnant women https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9359 Sat 24 Mar 2018 08:36:32 AEDT ]]> Sex-specific associations between cortisol and birth weight in pregnancies complicated by asthma are not due to differential glucocorticoid receptor expression https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9325 Sat 24 Mar 2018 08:33:54 AEDT ]]> Impaired type I and III interferon response to rhinovirus infection during pregnancy and asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14142 Sat 24 Mar 2018 08:24:51 AEDT ]]> A randomised trial of domiciliary, ambulatory oxygen in patients with COPD and dyspnoea but without resting hypoxaemia https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18137 Sat 24 Mar 2018 08:04:44 AEDT ]]> Combined haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21800 Haemophilus influenzae is one of the most commonly isolated bacteria. The relationship between chronic airway colonisation and the development of steroid-resistant neutrophilic asthma is unclear. Objectives: To investigate the relationship between H influenzae respiratory infection and neutrophilic asthma using mouse models of infection and ovalbumin (OVA)-induced allergic airways disease. Methods: BALB/c mice were intratracheally infected with H influenzae (day 10), intraperitoneally sensitised (day 0) and intranasally challenged (day 12–15) with OVA. Treatment groups were administered dexamethasone intranasally during OVA challenge. Infection, allergic airways disease, steroid sensitivity and immune responses were assessed (days 11, 16 and 21). Results: The combination of H influenzae infection and allergic airways disease resulted in chronic lung infection that was detected on days 11, 16 and 21 (21, 26 and 31 days after infection). Neutrophilic allergic airways disease and T helper 17 cell development were induced, which did not require active infection. Importantly, all features of neutrophilic allergic airways disease were steroid resistant. Toll-like receptor 4 expression and activation of phagocytes was reduced, but most significantly the influx and/or development of phagocytosing neutrophils and macrophages into the airways was inhibited. Conclusions: The combination of infection and allergic airways disease promotes bacterial persistence, leading to the development of a phenotype similar to steroid-resistant neutrophilic asthma and which may result from dysfunction in innate immune cells. This indicates that targeting bacterial infection in steroid-resistant asthma may have therapeutic benefit.]]> Sat 24 Mar 2018 07:59:21 AEDT ]]> Systemic upregulation of neutrophil α-defensins and serine proteases in neutrophilic asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17886 Sat 24 Mar 2018 07:56:18 AEDT ]]> Asthma-COPD overlap 2015: now we are six https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28283 Sat 24 Mar 2018 07:41:21 AEDT ]]> Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22009 Chlamydia and Haemophilus lung infection-induced SSIAAD. We used these models to investigate the effects of clarithromycin and amoxicillin treatment on immune responses and airways hyper-responsiveness (AHR) in Ova-induced, T helper lymphocyte (Th) 2 -associated steroid-sensitive AAD and infection-induced Th1/Th17-associated SSIAAD compared with dexamethasone treatment. Results: Clarithromycin and amoxicillin had similar antimicrobial effects on infection. Amoxicillin did attenuate some features, but did not broadly suppress either form of AAD. It did restore steroid sensitivity in SSIAAD by reducing infection. In contrast, clarithromycin alone widely suppressed inflammation and AHR in both steroid-sensitive AAD and SSIAAD. This occurred through reductions in Th2 responses that drive steroid-sensitive eosinophilic AAD and tumour necrosis factor a and interleukin 17 responses that induce SSIAAD. Conclusions: Macrolides have broad anti-inflammatory effects in AAD that are likely independent of their antimicrobial effects. The specific responses that are suppressed are dependent upon the responses that dominate during AAD.]]> Sat 24 Mar 2018 07:15:55 AEDT ]]> Inflammasomes in COPD and neutrophilic asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22105 Sat 24 Mar 2018 07:10:20 AEDT ]]> Effect of obesity on airway and systemic inflammation in adults with asthma: a systematic review and meta-analysis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53538 Mon 04 Dec 2023 15:44:36 AEDT ]]> Randomised controlled trial for the titration of oral corticosteroids using markers of inflammation in severe asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53104 Fri 17 Nov 2023 11:38:03 AEDT ]]> Inhaled pirfenidone solution (AP01) for IPF: A randomised, open-label, dose-response trial https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51684 Fri 15 Sep 2023 09:37:14 AEST ]]> Effectiveness of school-based self-management interventions for asthma among children and adolescents: findings from a cochrane systematic review and meta-analysis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37891 Fri 03 Dec 2021 10:34:20 AEDT ]]>